Bioactive Small Molecules
Medchemexpress LLC PKUMDL-LC-101-D04 250mg | 2143896-83-5 | 378.94 g/mol | C14H23ClN4O2S2 | 250 MG
This small-molecule allosteric activator of glutathione peroxidase 4 (GPX4) increases GPX4 enzymatic activity (reported pEC50 = 4.7), inhibits ferroptosis and inflammation in biochemical and cellular assays, and is supplied as a high-purity research reagent for laboratory studies.
- Activates GPX4 with reported pEC50 = 4.7.
- Increases GPX4 activity to approximately 150% in cell-free assays.
- Inhibits ferroptosis and associated inflammatory responses.
- High purity (≈99.9%) suitable for research applications.
- Soluble in DMSO at about 200 mg/mL for preparation of stock solutions.
- White to off-white solid; store sealed and away from moisture.
Medchemexpress LLC 19-Hydroxy cholester 1mg | 561-63-7 | 1 MG
19-Hydroxy cholesterol is a hydroxylated cholesterol metabolite supplied as a powdered biochemical reagent for research applications. It has CAS 561-63-7, chemical formula C27H46O2, and molecular weight 402.65. Typical purity is ≥99.0% (HPLC). Store frozen to preserve stability.
- High purity (≥99.0% by HPLC).
- Supplied as a stable powder for easy handling.
- Suitable as a reference standard in biochemical assays.
- Long-term storage at -20°C preserves integrity.
- Soluble in common organic solvents for assay preparation.
Medchemexpress LLC Hsp70-in-1 | 1268273-90-0 | 98.1% | 464.58 g/mol | C24H28N6O2S | 10MG
HSP70-IN-1 is a small-molecule inhibitor of the heat shock protein HSP70 developed for research applications. It inhibits Kasumi-1 cell growth with an IC50 of 2.3 μM and is supplied as a light yellow solid or as a 10 mM solution in DMSO. The compound is used in cellular assays to probe HSP70 function, cell-cycle regulation, and proteostasis-related pathways.
- Selective HSP70 inhibition for cellular assays.
- IC50 2.3 μM in Kasumi-1 cell growth assays.
- CAS number 1268273-90-0 for unambiguous identification.
- Molecular formula C24H28N6O2S; molecular weight 464.58 g/mol.
- High purity, 98.07% by supplier analysis.
- Appearance solid, light yellow to yellow.
- Soluble in DMSO, 50 mg/mL (≈107.6 mM); ultrasonic assistance recommended.
- Available in small research quantities and as a 10 mM DMSO solution.
![Medchemexpress LLC 7-(2-hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carb | 1231889-53-4 | MFCD30470964 | 99.1% | 502.56 g·mol⁻¹ | C31H26N4O3 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000246816.png-250.jpg)
Medchemexpress LLC 7-(2-hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carb | 1231889-53-4 | MFCD30470964 | 99.1% | 502.56 g·mol⁻¹ | C31H26N4O3 | 25 MG
BMS-935177 is a reversible, selective small-molecule inhibitor of Bruton's tyrosine kinase (BTK) for research use. It exhibits low-nanomolar biochemical potency and has been characterized for activity in cellular assays and oral efficacy in animal models relevant to B-cell signaling and immune modulation.
- Low-nanomolar BTK inhibition (IC50 3 nM).
- Cellular activity inhibiting calcium flux (IC50 27 nM) and CD69 expression.
- Reduces TNFα production in PBMC assays (IC50 14 nM).
- Demonstrated oral efficacy in rodent models with dose-dependent disease reduction.
- Solid, light yellow to yellow; purity 99.11%.
- Recommended storage: powder -20°C (long term); in solvent -80°C.
![Medchemexpress LLC N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine | 245520-69-8 | MFCD12910520 | 99.7% | 371.48 g·mol⁻¹ | C23H25N5 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000287277.png-250.jpg)
Medchemexpress LLC N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine | 245520-69-8 | MFCD12910520 | 99.7% | 371.48 g·mol⁻¹ | C23H25N5 | 10 MG
SCH79797 is a research-grade small molecule antagonist of protease-activated receptor 1 (PAR1). It selectively blocks PAR1-mediated signaling in cellular and preclinical models, reducing thrombin-induced responses and enabling studies of platelet aggregation, vascular signaling, and tissue injury mechanisms.
- Selective PAR1 antagonism with low-nanomolar potency (IC50 ≈ 70 nM)
- Inhibits thrombin-induced platelet aggregation in vitro
- Demonstrated antiproliferative and pro-apoptotic effects in preclinical studies
- Used in vascular, endothelial, and astrocyte signaling research
- High chemical purity reported (>99.7%)
- Intended for laboratory research use only
Medchemexpress LLC HY-130257 5mg Medchemexpress, CP5V CAS:2509359-75-3 Purity:>98%
Medchemexpress, HY-130257 5mg CP5V CAS:2509359-75-3 CP5V is a PROTAC, which specifically degrades Cdc20 by linking Cdc20 to the VHL/VBC complex for ubiquitination followed by proteasomal degradation. CP5V induces mitotic inhibition and suppresses cancer cell proliferation. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Zasocitinib | 2272904-53-5 | 99.2% | 460.49 | 1 ML
Zasocitinib (NDI-034858) is a TYK2 inhibitor, specifically targeting the TYK2 JH2 domain. It exhibits a binding constant (Kd) of less than 200 pM and is intended for research use only.
- Targets TYK2 JH2 domain.
- Binding constant (Kd) of <200 pM.
- Inhibits TYK2 and JAK at 10 μM.
- Inhibits phosphorylation induction of heterodimer complex TYK2/JAK2-mediated IL-12 effect in human peripheral blood mononuclear cells with an IC50 value of <0.1 μM.
![Medchemexpress LLC (E)-3-(3,4-dichlorophenyl)-N-[2-(4-methylsulfonylpiperazin-1-yl)-2-oxoethyl]prop-2-enamide | 2505001-62-5 | 99.6% | 420.31 g/mol | C16H19Cl2N3O4S | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00132390-HY-136530-5MG.JPG-250.jpg)
Medchemexpress LLC (E)-3-(3,4-dichlorophenyl)-N-[2-(4-methylsulfonylpiperazin-1-yl)-2-oxoethyl]prop-2-enamide | 2505001-62-5 | 99.6% | 420.31 g/mol | C16H19Cl2N3O4S | 5 MG
SR18662 is a small-molecule inhibitor of Krüppel-like factor 5 (KLF5) intended for research use. It demonstrates potent activity (IC50 ≈ 4.4 nM) and is supplied as a white to off-white solid, accompanied by analytical documentation to support experimental use.
- Potent KLF5 inhibition (IC50 ≈ 4.4 nM).
- High purity, supplied as a white to off-white solid.
- Available in small pack sizes for screening and follow-up studies.
- Includes analytical documentation such as COA, HNMR, and LCMS.
- Suitable for in vitro and in vivo research applications.
Cayman Chemical Cobicistat, Purity: ≥98%, CAS: 1004316-88-4, 10 mg
An inhibitor of CYP3A (IC50s = 30-285 nM for CYP3A metabolism of various HIV protease inhibitors); selective for CYP3A over other CYP isomers (IC50 = >25 μM for CYP1A2, 2C8, 2C9, and 2C19); does not inhibit HIV-1 protease (IC50 = >30 μM) or affect HIV replication in MT-2 cells (EC50 = >30 μM)
Medchemexpress LLC SX-682 SMALL MOLECULE CXCR 5MG
1648843-04-2, MFCD28502254,Formula C₁₉H₁₄BF₄N₃O₄S, Purity: 98.52%, Molecular Weight 467.20, SX-682 is an orally bioavailable, potent allosteric inhibitor of CXCR1 and CXCR2. SX-682 can block tumor myeloid-derived suppressor cells (MDSCs) recruitment and enhance T cell activation and antitumor immunity.
Medchemexpress LLC H-D-2-Nal-OH | 76985-09-6 | 215.25 | 10 G
H-D-2-Nal-OH is an alanine derivative that influences the secretion of anabolic hormones, supplies fuel during exercise, improves mental performance during stress-related tasks, and helps prevent exercise-induced muscle damage. It is recognized as a beneficial ergogenic dietary substance.
- Solid appearance
- White to off-white color
- Powder stable for 3 years at -20°C, 2 years at 4°C
- Soluble in water (1 mg/mL)
Apexbio Technology LLC Afuresertib 1047644-62-1 100mg
Afuresertib (CAS 1047644-62-1) is a small molecule inhibitor targeting the serine/threonine protein kinase Akt (also known as protein kinase B) a key component of the PI3K/Akt signaling pathway involved in cell proliferation survival and metabolism By inhibiting Akt activity afuresertib modulates downstream signaling cascades that contribute to oncogenesis and tumor progression This compound has been investigated in preclinical models and clinical trials for its potential to suppress malignant cell growth particularly in studies involving solid tumors and hematologic malignancies Its use facilitates exploration of Akt pathway inhibition in cancer research
Medchemexpress LLC GNE-886 | 2101957-05-3 | 99.8% | 498.58 | C28H30N6O3 | 50 MG
GNE-886 is a potent, selective small-molecule inhibitor of the CECR2 bromodomain used for epigenetic reader-domain research and cellular assays. Supplied as a 50 mg research sample with reported purity 99.81%, it has molecular formula C28H30N6O3 and molecular weight 498.58; reported potency is IC50 = 0.016 μM (CECR2) and EC50 = 370 nM in cellular assays.
- Potent and selective CECR2 bromodomain inhibition.
- High purity (99.81%) suitable for biochemical and cellular studies.
- Small-scale package for research use and lead optimization.
- Well-characterized by molecular formula and molecular weight.
- Datasheet and certificate of analysis available.
Medchemexpress LLC Cabozantinib impurity 1 | 918642-61-2 | MFCD16676129 | 1g
Cabozantinib impurity 1 is an impurity of Cabozantinib (HY-13016)